Low white blood cell count and cancer: MedlinePlus Medical Encyclopedia
White blood cell count. A white blood cell count, also called a leukocyte count, measures the total number of white blood cells in a sample of blood. These cells . SINGAPORE - Elevated white blood cell counts appear to be an was is a prospective relationship between circulating WBC count and cancer. Inflammation may be linked to the pathogenesis of colorectal cancer. However, two conflicting observational results were recently reported on the relationship.
Insured workers were excluded from this study population because there was no WBC record in their examinations. The 3, participants who reported a history of any cancer at enrollment and 1, participants who died of cancer before the start of follow-up were also excluded.
Additionally, 17, participants with missing data on any covariate information were excluded from the study. After these exclusions,participantsmen andwomen who received medical examination in and were included in the analyses.
Data collection Medical examinations were performed according to a standard procedure and conducted by the medical staffs at local hospitals. In the and questionnaires, participants were asked about smoking habits and other health behaviors. Participants were also asked if they were currently being treated for cancer or other diseases.
If so, they were asked for the date of diagnosis. The completed questionnaires were reviewed by trained staff and then entered into a database. The data were also checked and cleaned again during the analysis.
WBC, plasma glucose, and total cholesterol were measured under fasting conditions for routine clinical purposes. Each hospital had internal and external quality control procedures directed by the Korean Association of Laboratory Quality Control.
Alcohol consumption per day was categorized as follows: The maximum follow-up period was 10 years, from January 1, to December 31, The exact dates of completion of the survey form were not recorded.
Consequently, follow-up accrual began January 1 of the calendar year and ended in the year in which the survey form was completed.
High white blood cell count: Causes, types, and other imbalances
Subjects who completed a survey but died in the same calendar year were excluded. Because the study involved routinely collected medical data, it was not necessary to obtain individual participant consent. Cancer outcomes The primary outcomes were mortality and incidence risk of colon and rectal cancers based on the National Cancer Registry data and hospitalization records.
Although Korea has a National Cancer Registry, reporting may not have been complete during the follow-up period. Thus, hospital administration files were used to identify the date of diagnosis. Therefore, incident cancer cases were coded as occurring either upon registration with the National Cancer Registry or upon hospital admission due to cancer diagnosis. Mortality was ascertained from death certificates. A computerized search of death certificate data from the National Statistical Office in Korea was performed using the unique identification number assigned at birth.
Causes of death were assigned at the hospitals by trained abstractors.
The analysis was limited to those deaths assigned to the 10th revision of the International Classification of Diseases ICD C18, malignant neoplasm of colon; C19, malignant neoplasm of rectosigmoid junction; and C20, malignant neoplasm of rectum. Statistical analysis Based on WBC at enrollment, Chi-square tests and one-way analyses of variance were used to analyze the statistical differences among characteristics of the study participants.
Categorization of WBC into quartiles was based on the distribution of WBC among the study participants aged 40 to 95 years at baseline. Age-adjusted death and incidence rates were calculated for each WBC quartile and were directly standardized to the age distribution of the Korean population in Cox models were also used to assess the trends in risk with quartiles of WBC as a continuous variable.
Medicines The following medicines may help increase WBC counts. They can also help lower the risk of or treat infection. Colony-stimulating factors Colony-stimulating factors are special medicines called growth factors. They stimulate, or help, the bone marrow to make white blood cells, red blood cells and platelets.
Different types of growth factors stimulate the bone marrow to make different types of blood cells.
Granulocyte colony-stimulating factors G-CSFs stimulate the bone marrow to make granulocytes. Granulocyte-macrophage colony-stimulating factors GM-CSFs stimulate the bone marrow to make granulocytes and macrophages. Granulocytes and macrophages are types of WBCs. Sargramostim Leukine is a GM-CSF that may be used to help reduce the chance of developing infection and keep chemotherapy on schedule.What Does a Low White Blood Cell Count Mean?
Antibiotics Antibiotics are drugs that fight infections caused by bacteria and other micro-organisms. The healthcare team may prescribe antibiotics if your white blood cell count is too low, the risk of infection is high or they suspect you have an infection.
What to know about high white blood cell count
Other infection-fighting drugs, such as antiviral or antifungal drugs, may also be given. Antibiotics, antiviral or antifungal drugs are given by mouth orally or intravenously. The healthcare team will choose medicines based on the type of organism causing the infection.
Until lab reports identify the organism, you may be given an antibiotic that fights many kinds of bacteria. This type of drug is called a broad spectrum antibiotic. Special precautions Some people may have to be admitted to the hospital if their absolute neutrophil count ANC is too low. Special precautions are taken until the neutrophil count is 0.
You may not be allowed to have visitors.
High White Cell Counts Signal Cancer Death Risk
If you can have visitors, they may have to wash their hands and wear a protective mask or gown. Anyone who feels unwell and those who have been exposed to an infectious disease such as chickenpox or measles should not visit. Delaying treatment If the white blood cell count or ANC is too low, chemotherapy is sometimes stopped temporarily. Sometimes a lower dose of chemotherapy drugs is given to lessen the impact on white blood cell counts and reduce the risk of further delays in treatment.
Preventing infection Report any symptoms of infection to your doctor or healthcare team.
High white blood cell count Causes - Mayo Clinic
Do not take any medicines for a fever without checking first with the healthcare team. You can also take the following steps to help lower your risk of getting an infection.
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Practise good personal hygiene This is one of the most effective ways of avoiding infection. Wash your hands often during the day, especially before eating and after going to the bathroom. Carry a small bottle of hand sanitizer to clean your hands if a sink is not available.
Clean the anal area gently but thoroughly after a bowel movement. Take a warm, instead of hot, shower every day. Hot showers can dry out the skin. Gently pat skin dry rather than rubbing it briskly. Use a soft toothbrush or clean cloth to clean teeth and gums to avoid irritating the mouth. Use pads rather than tampons during menstruation. Protect your skin If your skin becomes dry or cracked, use moisturizing lotions to soften it and help it heal. The healthcare team or pharmacist can suggest lotions.
Wear rubber gloves when doing dishes, cleaning or gardening. Use cuticle cream or cuticle remover instead of tearing or cutting the cuticles. Do not squeeze or scratch pimples. Use an electric shaver instead of a razor to avoid cutting the skin.
Be especially careful to avoid burns when ironing or cooking. Clean any cut or scrape at once with warm water and soap. Maintain good general health Whenever possible, get enough rest, eat a well-balanced diet, drink plenty of fluids and get regular exercise. If you have low blood cell counts, take steps to protect yourself. Stay away from anyone who has a cold, the flu or an infectious disease like chicken pox, mumps, measles or shingles.
Talk to the healthcare team about vaccinations.