Relationship between lutein and cataracts

relationship between lutein and cataracts

Lutein and zeaxanthin and the risk of cataract: the Melbourne visual CONCLUSIONS: This study found an inverse association between high dietary LZ intake. This study was done to evaluate the relationships between nuclear cataracts, lutein and zeaxanthin in the diet, serum and macula in a study of women aged 50 . The Association of Dietary Lutein/Zeaxanthin and B Vitamins with Cataracts in the .. We accounted for the correlation between eyes using an exchangeable.

This interaction between UVB exposure that causes oxidative lens damage and vitamin E intake that provides an antioxidative effect has been explored in detail for the baseline Melbourne VIP, where ocular ultraviolet B exposure was not independently related to nuclear cataract. The mean age of those who completed the FFQ was The FFQ included 13 different fruit items and 25 vegetable items, and each item had 10 available frequency options from never to three or more times per day.

Software developed by the Cancer Council Victoria was used to compute nutrient intakes from the FFQ, by using carotenoid composition data from the U. We fitted the logistic regressions for the by-person analyses and the generalized linear models for the by-eye analyses. The generalized linear models with an unstructured working correlation matrix were used to account for dependency between two eyes from the same participant. We compared eyes with pure cortical cataract versus eyes with no cataract in the by-eye analyses.

We did similar analyses for nuclear and PSC cataract. Multivariate models included either crude or energy-adjusted LZ intakes, and covariates found important in the baseline analysis of the VIP cohort. However, this interaction was not significant and was not included in the multivariate analyses. The probability for trend in a multivariate analysis was derived from the test of whether the coefficient for the quintile medians was equal to zero.

Of the total respective samples, 9. We present the by-person analyses Table 2. There were, and eyes included in the by-eye analyses for cortical, nuclear, and PSC cataract, respectively.

relationship between lutein and cataracts

From the by-person analyses, older people had a significantly higher risk of having any kind of cataract. The odds ratios were all approximately equal to 0. The odds ratios and probabilities for LZ intake from the by-person analyses were similar to those from the by-eye analyses, when we compared eyes with pure cataract of specific type versus eyes having had no cataract of this type data not shown.

Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project.

For cortical and PSC cataract, the results for excluding those who took supplements were not much different from those for all participants. Discussion Our study showed an inverse association between higher dietary LZ intake and the presence of nuclear cataract.

relationship between lutein and cataracts

This finding was consistent with other epidemiologic studies. Also, we collected information for many confounders. One limitation of this study is that the data are cross-sectional. The mean age of those included in the multivariate analyses was significantly less than the mean age of those lost to follow-up or excluded from the multivariate analyses for each kind of cataract; the differences in mean ages were 3.

However, most of the odds ratios were similar to those in the previously published baseline analyses, 5 suggesting they were not affected by selection bias. Most previous studies of cataract have collected the cataract outcomes and dietary intake data at the same time, 7 8 whereas an association between past LZ intake and cataract incidence would be more valuable in studying cause—effect associations.

Thus, in the Beaver Dam Eye Study, LZ intake 10 years before baseline was associated with incidence of nuclear cataract over the after 5 years, whereas current dietary intake showed little association.

However, the odds ratios for every 1-mg increase in both crude or energy-adjusted daily LZ intake for either cortical or PSC cataract were similar to those for nuclear cataract. Therefore, a larger sample size would be needed to detect a possible association between LZ intake and risk of either cortical or PSC cataract.

We used the estimates derived from the multivariate logistic regressions to calculate these powers. For any type of cataract and any type of analysis, the means of LZ intake were greater for noncases than for cases, and the means of LZ intake were greater for those who took supplements than for those who did not take supplements.

relationship between lutein and cataracts

Published online Jan This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license http: This article has been cited by other articles in PMC. Abstract The purpose of this meta-analysis was to evaluate the relationship between blood lutein and zeaxanthin concentration and the risk of age-related cataract ARC.

Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project.

Meta-analysis was conducted to obtain pooled relative risks RRs for the highest-versus-lowest categories of blood lutein and zeaxanthin concentrations. One cohort study and seven cross-sectional studies were included in the meta-analysis.

There were significant inverse associations between nuclear cataract and blood lutein and zeaxanthin concentrations, with the pooled RRs ranging from 0.

relationship between lutein and cataracts

A stronger association between nuclear cataract and blood zeaxanthin might be noted for the studies conducted in the European Nations. Blood lutein and zeaxanthin were also noted to lead towards a decrease in the risk of cortical cataract and subcapsular cataract; however, these pooled RRs were not statistically significant, with the exception of a marginal association between lutein and subcapsular cataract.

Our results suggest that high blood lutein and zeaxanthin are significantly associated with a decrease in the risk of nuclear cataract. However, no significant associations were found for ARC in other regions of the lens. Introduction Cataract is a clouding or opacification of the lens inside the eye that obstructs the passage of light [ 1 ].

Age-related cataract ARC is the leading causes of blindness and vision impairment worldwide [ 2 ]. It was estimated that 20 million people older than 40 years were visually impaired due to ARC in the United States [ 3 ].

Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis

Although new therapeutic methods emerged in recent years and most ARC cases can be cured, the high treatment costs and increasing demands for therapy will challenge the long-term economic stability of health care systems [ 4 ].

With the rapidly aging population, ARC has brought a massive burden on health care and become an important public health issue. Thus, identifying modifiable factors available to prevent or delay the development of ARC is a crucial strategy. Light-initiated oxidative damages are hypothesized to be the mechanism involved in ARC [ 5 ].

The xanthophyll carotenoids lutein and zeaxanthin are uniquely concentrated in the lens, where they can attenuate photochemical damage by filtering high-energy short-wavelength light [ 67 ].

Association between Lutein and Zeaxanthin Status and the Risk of Cataract: A Meta-Analysis

In addition, they serve to protect the lens from oxidative damage by scavenging reactive oxygen species ROSindicating that these carotenoids may play a potentially important role in the prevention of ARC [ 8 ]. Numerous epidemiological studies have investigated the relationship between dietary intake and blood levels of lutein and zeaxanthin and the risk of ARC [ 910 ].

Because the accuracy of dietary intake measurements is greatly influenced by the different dietary assessment methods across the studies and the individual differences in utilization and absorption, blood concentrations appears to be a stronger predictor of nutritional status [ 1112 ].

relationship between lutein and cataracts