Collagen and cartilage relationship

Collagen: An implausible supplement for joint pain – Science-Based Medicine

collagen and cartilage relationship

Nov 10, Stage 2 progresses to erosion of the cartilage and a release of collagen The latest supplement trend for joint pain may be collagen. With Genacol, a “ statistically significant” beneficial effect with relation to pain was. teinases, nor in the synthesis of type II collagen and the con- tent of the .. II collagen in articular cartilage in ageing and osteoarthritis and their relationship to . Cartilage is a resilient and smooth elastic tissue, a rubber-like padding that covers and protects . This implies that the cartilage is fibrillar-collagen-based.

All animals are mainly collagen: Think of it as a collagen coat. Or think of scurvy — now rare, but once the worst thing about extended sea voyages. Vitamin C is a necessary cofactor for collagen synthesis. Without it, multiple systems are affected, and biological disaster ensues, starting with your teeth falling out.

collagen and cartilage relationship

When we consume collagen, usually in the form of food, the long chain proteins are broken down during digestion to their original amino acids. Only then can they be absorbed. Once absorbed, these amino acids are available as building blocks to support collagen synthesis throughout the body.

For this reason, the idea that collagen supplementation can be an effective treatment for joint pain, osteoarthritis, or any other condition, is highly implausible, if not impossible in principle.

Study of Altered Mechanical Properties of Articular Cartilage in Relation to the Collagen Network

But about that proof … The company links to a press release with its scientific evidence for Genacol. Two clinical trials are described. A search of PubMed reveals neither have been published.

A tiny change in pain may be enough to be statistically significant — but is it relevant in the real world? We only have the abstracts, so the information is incomplete.

  • Collagen Vs. Cartilage
  • The minor collagens in articular cartilage
  • Collagen: An implausible supplement for joint pain

The first trial, A 6-month randomised, double-blind, placebo controlled study to assess the clinical benefit of a food supplement made of a proprietary collagen hydrolysate in subjects with joint pain at the lower or upper limbs or at the lumbar spine randomized patients to mg of collagen daily, or placebo.

At 6 months, the proportion of clinical responders to the treatment, according to VAS scores, was significantly higher in the collagen hydrolysate CH group Using other pain and function assessment tools i. The second trial is also lacking in information. A randomized controlled trial on the efficacy of oral collagen treatment on the medial knee joint space and functional outcome among veterans memorial medical center patients diagnosed with osteoarthritis of the knee: Right away, that many patient dropouts is a massive red flag, as patients that drop out usually are not responding to treatment.

Cartilage Regeneration

Both groups could use ketoprofen gel as desired. There was no significant difference in the medial knee joint space measured at baseline and after six months in both groups. Given the trial was single-blind, the risk of bias is large. Perhaps not surprisingly, when objective measurements joint spaces were taken, there were no differences between the groups.

collagen and cartilage relationship

Genacol, like other collagen supplements, appears to be little more than an expensive protein supplement. If you want to supplement with collagen, my suggestion is to skip the supplements, and go for a well-marbled steak.

Study of Altered Mechanical Properties of Articular Cartilage in Relation to the Collagen Network

Approximately one quarter of all the protein in your body is collagen. Collagen is the main protein found in connective tissue. Cartilage is one type of connective tissue comprised of cells called chondrocytes and a strong, flexible matrix of collagen, protein and sugar. Collagen and cartilage perform different roles, but your body depends on both to function normally.

What Collagen and Cartilage Have in Common Strength and the ability to bend under tension are two characteristics of collagen, which is the main component in ligaments and tendons. Ligaments bind bones to bones while tendons bind muscles to bones. The strength and flexibility of collagen allow you to move with ease. Strength and flexibility are two characteristics of cartilage, which cover the ends of your bones at a joint.

Collagen Vs. Cartilage | Healthfully

Cartilage allows one bone to glide over another as it protects and prevents bones from rubbing against each other. How Collagen and Cartilage Differ Apart from their complimentary roles in the skeletomuscular system, collagen and cartilage have different and distinct functions in your body. There are three types of cartilage -- hyaline, elastic and fibrocartilage. Hyaline is the most abundant type of cartilage in your body. It is the supportive tissue in your ears, nose, trachea, larynx and smaller respiratory tubes.

In addition to cushioning your bones at a joint, hyaline cartilage is found where the ribs attach to the sternum. Elastic cartilage is found in your earlobes, eusatachian tubes and epiglottis.